Bimodal gene expression patterns in breast cancer

BMC Genomics

Research

Yuri Nikolsky¹  Andrej Bugrim¹  Weiwei Shi¹  Marina Bessarabova²  Tatiana Nikolskaya²  Eugene Kirillov² 

[1] Genego, Inc., 500 Renaissance Drive, 49085, St. Joseph, MI, USA;Russian Academy of Sciences, Vavilov Institute for General Genetics, ul. Gubkina, 3, Moscow, Russia;

关键词: Breast Cancer;    Close Neighbor;    Microarray Platform;    Group Expression;    cDNA Array;   

DOI  :  10.1186/1471-2164-11-S1-S8

来源: Springer

【 摘 要 】

We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. The groups tend to form concise network modules underlying their function in cancerogenesis of breast neoplasms.

【 授权许可】

Unknown   
© Bessarabova et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.