Visit-to-visit blood pressure variability is a marker of cardiac diastolic function and carotid atherosclerosis

BMC Cardiovascular Disorders

Research Article

Mamoru Nanasato¹  Kenji Wakai²  Rieko Okada²  Akira Okada³  Takashi Okada³ 

[1] Cardiovascular Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan;Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan;Okada Medical Clinic, Nagoya, Japan;

关键词: Diastolic Dysfunction;    Diastolic Function;    Leave Ventricular Mass Index;    Carotid Atherosclerosis;    Blood Pressure Variability;   

DOI  :  10.1186/1471-2261-14-188

 received in 2014-09-26, accepted in 2014-12-11,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe associations between visit-to-visit blood pressure (BP) variability and cardiac function and carotid atherosclerosis is not clear.MethodsStudy subjects were 144 subjects (80 were female, aged 73 ± 9 years) who underwent echocardiography and cervical ultrasonography. The ratio of early ventricular filling velocity to early diastolic mitral annular velocity (E/e’), ejection fraction, left ventricular mass index (LVMI), and maximum intima-media thickness (max-IMT) of the carotid artery were compared between the highest (high variability) and lowest (low variability) tertiles of the standard deviation of systolic BP (9.9 ± 3.5 mmHg).ResultsE/e’ and max-IMT were significantly greater in the high variability group than in the low variability group after adjusting for age, sex, baseline systolic BP, and other covariates (high variability vs. low variability; E/e’: 13.03 ± 5.33 vs. 10.66 ± 3.30, multivariate-adjusted difference (β) = 1.82, 95% confidence interval 0.06–3.58; max-IMT: 1.65 ± 0.43 mm vs. 1.42 ± 0.46 mm, β = 0.20 mm, 95% confidence interval 0.03–0.36 mm). There were no significant differences in LVMI or ejection fraction.ConclusionThese results indicate that high visit-to-visit BP variability is associated with diastolic function and carotid atherosclerosis, and is a possible risk factor for diastolic dysfunction and atherosclerosis.

【 授权许可】

CC BY   
© Okada et al.; licensee BioMed Central Ltd. 2014