Correlation of intestinal microbiota with overweight and obesity in Kazakh school children

BMC Microbiology

Research Article

Jihong Zhang¹  Min Li²  Peiru Xu²  Tao Zhang³ 

[1] Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, 840054, Urumqi, Xinjiang Uyghur Autonomous Region, People’s Republic of China;Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, 840054, Urumqi, Xinjiang Uyghur Autonomous Region, People’s Republic of China;Xinjiang Evidence-based Medicine Research Institute, 137 Liyushan South Road, 830054, Urumqi, Xinjiang, Uyghur Autonomous Region, People’s Republic of China;Department of Urology, Second Affiliated Hospital of Xinjiang Medical University, 38 nanhu East Road, 830063, Urumqi, Xinjiang Uyghur Autonomous Region, People’s Republic of China;

关键词: Bacteroidetes;    Firmicutes;    Kazakh;   

DOI  :  10.1186/1471-2180-12-283

 received in 2012-03-28, accepted in 2012-11-15,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThis study sought to investigate a possible correlation between the intestinal microbiota, Bacteroidetes and Firmicutes, and obesity in Kazakh school children, aged 7–13 (n = 175).ResultsObese subjects had significantly greater systolic blood pressure, waist and hip circumference, as well as HOMA-IR as compared to normal and overweight participants. In addition, Bacteroides copy number and Bact/Firm ratios were significantly lower in the obese group as compared to the normal and overweight groups (P < 0.0167). This difference is only significant in girls, but not in boys when stratified by gender. Furthermore, a negative correlation between BMI and Bacteroidetes copy number (r = −0.18, P = 0.017) as well as Bact/Firm (r = −0.22, P = 0.003) was observed.ConclusionAn association between reduced gut Bacteroidetes and Bact/Firm ratio with obesity in female Kazakh children was identified. Further studies are necessary to elucidate the mechanism behind these changes as well as the value of determining their presence for predicting obesity.

【 授权许可】

CC BY   
© Xu et al.; licensee BioMed Central Ltd. 2012