期刊论文详细信息
BMC Family Practice
Impact of medication adherence on renal function in comorbid patients with type 2 diabetes and depression: protocol for a cohort study
Study Protocol
Tosiya Sato1  Mitsuhiko Noda2  Hiroto Ito3  Noriko Satoh-Asahara4 
[1] Department of Biostatistics, Kyoto University School of Public Health, Kyoto, Japan;Department of Diabetes and Metabolic Medicine, National Centre for Global Health and Medicine, Tokyo, Japan;Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan;Division of Diabetic Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;
关键词: Chronic kidney disease;    Depression;    Medication adherence;    Protocol;    Type 2 diabetes;   
DOI  :  10.1186/s12875-015-0339-1
 received in 2015-07-07, accepted in 2015-09-09,  发布年份 2015
来源: Springer
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【 摘 要 】

BackgroundPrevention, or slowing the progression, of diabetic nephropathy is one of the important goals in diabetes care. Although the impact of depression is a concern in patients with diabetes, it is unknown whether there is an association between adherence to hypoglycemic medication and the decline of renal function in comorbid patients with diabetes and depression. We will conduct a cohort study aimed at examining (1) depression as a predictor of renal function decline, and (2) how adherence to hypoglycemic medication relates to depression and renal function decline in patients with type 2 diabetes.Methods/DesignIn this multicenter cohort study, 550 patients with type 2 diabetes aged 20 years and older will be recruited at 20 outpatient clinics in general medicine and psychiatry. We will measure depression (Patient Health Questionnaire), medication adherence (medication possession ratio, Morisky Medication Adherence Scale, and one-item hypoglycemic medication adherence scale), and renal function (urinary albumin-creatinine ratio and estimated glomerular filtration rate) at baseline and at the 12-month follow-up. The primary endpoint is decline of renal function at 12 months. The secondary endpoints include clinical variables, quality of life, and the attitude of professionals toward depression. We will perform multivariable linear regression analysis to evaluate the effects of medication adherence on the decline of renal function in comorbid patients with type 2 diabetes and depression.DiscussionTo our knowledge, this will be the first study to examine how adherence to hypoglycemic medication relates to the decline of renal function in comorbid patients with type 2 diabetes and depression. The results of the study will have implications for practitioners of diabetes care, policy makers, and researchers for the prevention and treatment of diabetic nephropathy.Trial registrationUMIN000017513 (Registered on May 22, 2015) 

【 授权许可】

CC BY   
© Ito et al. 2015

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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
  • [27]
  • [28]
  • [29]
  • [30]
  • [31]
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