Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms

BMC Gastroenterology

Research Article

Kazuhiro Kaneko¹  Hiroaki Ikematsu¹  Kuang-I Fu²  Yasushi Sano³  Takahiro Fujimori⁴  Yutaka Saito⁵  Takahisa Matsuda⁵  Fabian Emura⁶  Toshio Uraoka⁷  Atsushi Ochiai⁸ 

[1] Department of GI Oncology & Endoscopy, National Cancer Center East Hospital, Chiba, Japan;Department of GI Oncology & Endoscopy, National Cancer Center East Hospital, Chiba, Japan;Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan;Department of GI Oncology & Endoscopy, National Cancer Center East Hospital, Chiba, Japan;Sano Hospital, Gastrointestinal Center, Kobe, Japan;Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan;Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan;Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan;Advanced Digestive Endoscopy, Emura Center Latino America & Emura Foundation for the Promotion of Cancer Research, Universidad deLa Sabana, Medical School Bogotá, Colombia;Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan;Department of Endoscopy, Okayama University Hospital, Okayama, Japan;Pathology Division, National Cancer Center Research Institute East, Chiba, Japan;

关键词: Positive Predictive Value;    Narrow Band Image;    National Cancer Center Hospital;    Indigo Carmine;    Early Colorectal Cancer;   

DOI  :  10.1186/1471-230X-10-33

 received in 2009-08-03, accepted in 2010-03-27,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundCapillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aimed to determine whether CP type IIIA/IIIB identified by magnifying NBI is effective for estimating the depth of invasion in early colorectal neoplasms.MethodsA series of 127 consecutive patients with 130 colorectal lesions were evaluated from October 2005 to October 2007 at the National Cancer Center Hospital East, Chiba, Japan. Lesions were classified as CP type IIIA or type IIIB according to the NBI CP classification. Lesions were histopathologically evaluated. Inter and intraobserver variabilities were assessed by three colonoscopists experienced in NBI.ResultsThere were 15 adenomas, 66 intramucosal cancers (pM) and 49 submucosal cancers (pSM): 16 pSM superficial (pSM1) and 33 pSM deep cancers (pSM2-3). Among lesions diagnosed as CP IIIA 86 out of 91 (94.5%) were adenomas, pM-ca, or pSM1; among lesions diagnosed as CP IIIB 28 out of 39 (72%) were pSM2-3. Sensitivity, specificity and diagnostic accuracy of the CP type III for differentiating pM-ca or pSM1 (<1000 μm) from pSM2-3 (≥1000 μm) were 84.8%, 88.7 % and 87.7%, respectively. Interobserver variability: κ = 0.68, 0.67, 0.72. Intraobserver agreement: κ = 0.79, 0.76, 0.75ConclusionIdentification of CP type IIIA/IIIB by magnifying NBI is useful for estimating the depth of invasion of early colorectal neoplasms.

【 授权许可】

Unknown   
© Ikematsu et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.