Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana

Malaria Journal

Research

Sihem Ouar-Epelboin¹  Matthieu Hanf²  Mathieu Nacher²  Bernard Carme²  Loïc Epelboin³  Philippe Dussart⁴  Félix Djossou⁵ 

[1] CIC-EC Antilles Guyane CIE 802 Inserm, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana;CIC-EC Antilles Guyane CIE 802 Inserm, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana;Research team EPaT EA 3593, University of French West Indies and French Guiana, Cayenne, French Guiana;CIC-EC Antilles Guyane CIE 802 Inserm, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana;Research team EPaT EA 3593, University of French West Indies and French Guiana, Cayenne, French Guiana;Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Pitié-Salpêtrière, 47–83 bd de l’Hôpital, 75013, Paris, France;Centre National de Référence des Arboviroses, Institut Pasteur de Guyane, Cayenne, French Guiana;Research team EPaT EA 3593, University of French West Indies and French Guiana, Cayenne, French Guiana;Infectious and Tropical Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana;

关键词: Dengue;    Malaria;    French Guiana;    Thrombocytopaenia;    Case–control studies;   

DOI  :  10.1186/1475-2875-11-142

 received in 2012-01-11, accepted in 2012-05-01,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDengue and malaria are two major arthropod-borne infections in tropical areas, but dual infections were only described for the first time in 2005. Reports of these concomitant infections are scarce and there is no evidence of more severe clinical and biological pictures than single infections.MethodsTo compare co-infections to dengue alone and malaria alone, a retrospective matched-pair study was conducted between 2004 and 2010 among patients admitted in the emergency department of Cayenne hospital, French Guiana.Results104 dengue and malaria co-infection cases were identified during the study period and 208 individuals were matched in two comparison groups: dengue alone and malaria alone. In bivariate analysis, co-infection clinical picture was more severe than separated infections, in particular using the severe malaria WHO criteria. In multivariate analysis, independent factors associated with co-infection versus dengue were: masculine gender, CRP level > 50 mg/L, thrombocytopaenia < 50 109/L, and low haematocrit <36% and independent factors significantly associated with co-infections versus malaria were red cells transfusion, low haematocrit < 36%, thrombocytopaenia < 50 109/L and low Plasmodium parasitic load < 0.001%.ConclusionsIn the present study, dengue and malaria co-infection clinical picture seems to be more severe than single infections in French Guiana, with a greater risk of deep thrombocytopaenia and anaemia.

【 授权许可】

CC BY   
© Epelboin et al.; licensee BioMed Central Ltd. 2012