eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population

Lipids in Health and Disease

Research

Masako Shigeta¹  Keizo Ohnaka²  Yoshikuni Kita³  Hideshi Niimura⁴  Takeshi Imaizumi⁵  Kokichi Arisawa⁶  Mariko Naito⁷  Sayo Kawai⁷  Takahiro Higashibata⁷  Kenji Wakai⁷  Nobuyuki Hamajima⁷  Guang Yin⁷  Sadao Suzuki⁸  Haruo Mikami⁹  Hideo Tanaka^1,10  Hidemi Ito^1,10  Michiaki Kubo^1,11 

[1] Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan;Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan;Department of Health Science, Shiga University of Medical Science, 520-2192, Otsu, Japan;Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science, 890-8544, Kagoshima, Japan;Department of Preventive Medicine, Faculty of Medicine, Saga University, 849-8501, Saga, Japan;Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, 770-8503, Tokushima, Japan;Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, 466-8550, Showa-ku, Nagoya, Japan;Department of Public Health, Nagoya City University Graduate School of Medical Sciences, 467-8601, Nagoya, Japan;Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center, 260-8717, Chiba, Japan;Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 464–8681, Nagoya, Japan;Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, 230-0045, Yokohama, Japan;

关键词: Cross-sectional study;    Gene-environment interaction;    Hypertriglyceridemia;    Lifestyle-related disease;    NOS3;    Tailoring prevention;   

DOI  :  10.1186/1476-511X-11-150

 received in 2012-08-13, accepted in 2012-10-27,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundNitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia.MethodsFor this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008.ResultsIn a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism.ConclusionsThis study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.

【 授权许可】

CC BY   
© Higashibata et al.; licensee BioMed Central Ltd. 2012