Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data

BMC Medicine

Research Article

Martin Bobak¹  Julian Gardiner¹  Anne Peasey¹  Hynek Pikhart¹  Kai-Uwe Saum²  Hermann Brenner³  Ben Schöttker³  Abdonas Tamosiunas⁴  Andrzej Pająk⁵  Roman Topor-Madry⁵  Eugène HJM Jansen⁶  Růžena Kubínová⁷  Bernd Holleczek⁸ 

[1] Department Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT, London, Great Britain;Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany;Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany;Network Aging Research, University of Heidelberg, Bergheimer Strasse 20, 69120, Heidelberg, Germany;Institute of Cardiology of Lithuanian University of Health Sciences, Kaunas, Lithuania;Jagiellonian University Medical College, Faculty of Health Sciences, Krakow, Poland;Laboratory for Health Protection Research, National Institute for Public Health and the Environment, PO Box 1, 3720, Bilthoven, BA, The Netherlands;National Institute of Public Health, Prague, Czech Republic;Saarland Cancer Registry, Präsident Baltz-Strasse 5, 66119, Saarbrücken, Germany;

关键词: Cancer mortality;    Cardiovascular mortality;    Cohort study;    Death;    Epidemiology;    Free radicals;    Meta-analysis;    Mortality;    Oxidative stress;   

DOI  :  10.1186/s12916-015-0537-7

 received in 2015-08-21, accepted in 2015-11-26,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe free radical/oxidative stress theory of ageing has received considerable attention, but the evidence on the association of oxidative stress markers with mortality is sparse.MethodsWe measured derivatives of reactive oxygen metabolite (D-ROM) levels as a proxy for the reactive oxygen species concentration and total thiol levels (TTL) as a proxy for the redox control status in 10,622 men and women (age range, 45–85 years), from population-based cohorts from Germany, Poland, Czech Republic, and Lithuania, of whom 1,702 died during follow-up.ResultsBoth oxidative stress markers were significantly associated with all-cause mortality independently from established risk factors (including inflammation) and from each other in all cohorts. Regarding cause-specific mortality, compared to low D-ROM levels (≤340 Carr U), very high D-ROM levels (>500 Carr U) were strongly associated with both cardiovascular (relative risk (RR), 5.09; 95 % CI, 2.67–9.69) and cancer mortality (RR, 4.34; 95 % CI, 2.31–8.16). TTL was only associated with CVD mortality (RR, 1.30; 95 % CI, 1.15–1.48, for one-standard-deviation-decrease). The strength of the association of TTL with CVD mortality increased with age of the participants (RR for one-standard-deviation-decrease in those aged 70–85 years was 1.65; 95 % CI, 1.22–2.24).ConclusionsIn these four population-based cohort studies from Central and Eastern Europe, the oxidative stress serum markers D-ROM and TTL were independently and strongly associated with all-cause and CVD mortality. In addition, D-ROM levels were also strongly associated with cancer mortality. This study provides epidemiological evidence supporting the free radical/oxidative stress theory of ageing and suggests that d-ROMs and TTL are useful oxidative stress markers associated with premature mortality.

【 授权许可】

CC BY   
© Schöttker et al. 2015