Genes encoding hub and bottleneck enzymes of the Arabidopsismetabolic network preferentially retain homeologs through whole genome duplication

BMC Evolutionary Biology

Research Article

Xiaoquan Qi¹  Xudong Wu¹ 

[1] Key Laboratory of Photosynthesis and Environmental Molecular Physiology, the Institute of Botany, Chinese Academy of Sciences, 100093, Beijing, China;

关键词: Metabolic Network;    Genome Duplication;    Whole Genome Duplication;    Genome Duplication Event;    Topological Centrality;   

DOI  :  10.1186/1471-2148-10-145

 received in 2010-01-12, accepted in 2010-05-18,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWhole genome duplication (WGD) occurs widely in angiosperm evolution. It raises the intriguing question of how interacting networks of genes cope with this dramatic evolutionary event.ResultsIn study of the Arabidopsis metabolic network, we assigned each enzyme (node) with topological centralities (in-degree, out-degree and between-ness) to measure quantitatively their centralities in the network. The Arabidopsis metabolic network is highly modular and separated into 11 interconnected modules, which correspond well to the functional metabolic pathways. The enzymes with higher in-out degree and between-ness (defined as hub and bottleneck enzymes, respectively) tend to be more conserved and preferentially retain homeologs after WGD. Moreover, the simultaneous retention of homeologs encoding enzymes which catalyze consecutive steps in a pathway is highly favored and easily achieved, and enzyme-enzyme interactions contribute to the retention of one-third of WGD enzymes.ConclusionsOur analyses indicate that the hub and bottleneck enzymes of metabolic network obtain great benefits from WGD, and this event grants clear evolutionary advantages in adaptation to different environments.

【 授权许可】

CC BY   
© Wu and Qi; licensee BioMed Central Ltd. 2010