Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus

World Journal of Surgical Oncology

Research

Li-Song Teng¹  Jie Wu²  Wei-Ming Mao³  Qi-Xun Chen³  Xing-Ming Zhou³  Mark J. Krasna⁴ 

[1] Department of Surgical Oncology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, 310033, Hangzhou, China;Department of Surgical Oncology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, 310033, Hangzhou, China;Department of Thoracic Surgery, Zhejiang Cancer Hospital, 310022, Hangzhou, China;Department of Thoracic Surgery, Zhejiang Cancer Hospital, 310022, Hangzhou, China;Meridian Cancer Care, Jersey Shore University Medical Center, 07753, Neptune, NJ, USA;

关键词: Esophageal cancer;    Solitary lymph node;    Prognosis;    Lymphadenectomy;   

DOI  :  10.1186/1477-7819-10-210

 received in 2012-08-12, accepted in 2012-09-18,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe aim of this study is to compare clinical outcomes between patients with solitary lymph node metastasis and node-negative (N0) patients in squamous cell carcinoma of the middle thoracic esophagus.MethodsA series of 135 patients with squamous cell carcinoma of the middle thoracic esophagus were retrospectively investigated. There were 33 patients with solitary lymph node metastasis and 102 N0 patients. Skip metastasis in 33 patients with solitary lymph node metastasis was defined according to three criteria: Japanese Society for Esophageal Disease (JSED), American Joint Commission on Cancer (AJCC), and the anatomical compartment.ResultsIn 33 patients with solitary lymph node metastasis, skip metastasis was shown in 13, 23, and 8 patients according JSED, AJCC and anatomical compartment respectively. The 5-year survival rates for N0 patients and patients with solitary lymph node metastasis were 58% and 32% respectively (P =0.008). Multivariate analysis revealed that skip metastasis was not an independent prognostic factor.ConclusionsFor patients with middle thoracic esophageal squamous cell carcinoma, solitary lymph node metastasis has a negative impact on survival compared with N0 disease; skip metastasis, however, is comparable to N0 diseases in predicting prognosis.

【 授权许可】

Unknown   
© Wu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.