LDL-cholesterol and body mass index among Japanese schoolchildren: a population-based cross-sectional study

Lipids in Health and Disease

Research

Takako Shirasawa¹  Tadahiro Ohtsu¹  Hiromi Hoshino¹  Hirotaka Ochiai¹  Akatsuki Kokaze¹  Aya Morimoto²  Rimei Nishimura²  Naoko Tajima³ 

[1] Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, 142-8555, Shinagawa-ku, Tokyo, Japan;Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan;Jikei University School of Medicine, Tokyo, Japan;

关键词: Serum low-density lipoprotein;    Body mass index;    Schoolchildren;   

DOI  :  10.1186/1476-511X-12-77

 received in 2013-03-29, accepted in 2013-05-20,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundSerum low-density lipoprotein cholesterol (LDL-C) is one of the most important risk factors for coronary heart disease. The aim of the present study was to investigate the relationship between LDL-C and body mass index (BMI) in population-based Japanese schoolchildren.MethodsThe subjects comprised all fourth graders and seventh graders in Ina Town, Saitama Prefecture, Japan, during 2002-2009. Information about each subject’s age, sex, and family history of hypercholesterolemia was collected using a self-administered questionnaire. The body height, weight, and LDL-C were measured for each child. LDL-C was measured using the direct method. According to the LDL-C criteria of the Japan Atherosclerosis Society, LDL-C level was categorized into three subgroups: acceptable, < 110 mg/dL; borderline, 110-139 mg/dL; and high, ≥ 140 mg/dL. Children with either borderline or high LDL-C level were considered to have high-normal LDL-C (HLDL-C).ResultsData from a total of 5869 subjects were analyzed. A higher BMI category was associated with a higher prevalence of HLDL-C regardless of sex or grade level (P < 0.05). When compared with the <50th percentile BMI category, the odds ratio (OR) for HLDL-C was statistically significant in the 75th to 84th percentile category of fourth-grade boys (OR: 1.95, 95% confidence interval (95% CI): 1.28-2.97), the 85th to 94th percentile of fourth-grade girls (2.52, 1.74-3.64), and the 85th to 94th percentile of seventh-grade boys (2.04, 1.31-3.20) and girls (1.90, 1.24-2.91).ConclusionA statistically significant association between LDL-C levels and BMI was observed in Japanese school children.

【 授权许可】

CC BY   
© Shirasawa et al.; licensee BioMed Central Ltd. 2013