Factors influencing hemorrhagic transformation in ischemic stroke patients with atrial fibrillation: a hospital based-study

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Research

Hala Ahmad Fathy Hafez¹  Bothina M. Ramadan¹  Rasha M. Fahmi¹  Takwa H. M. Elkhatib¹ 

[1] Neurology Department, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt;

关键词: Ischemic stroke;    Atrial fibrillation;    Hemorrhagic transformation;    Infarction size;    Cerebral microbleed;   

DOI  :  10.1186/s41983-023-00739-y

 received in 2023-06-16, accepted in 2023-10-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPatients with ischemic stroke and atrial fibrillation (AF) are at high risk of developing hemorrhagic transformation (HT). The aim of the current study is to evaluate the incidence of hemorrhagic transformation and associated risk factors in a hospital-based sample with ischemic stroke and AF patients. A prospective study with a total of 234 stroke patients with AF was consecutively recruited. HT incidence was determined by computed tomography (CT) or magnetic resonance imaging (MRI). Risk factors associated with HT was identified by comparing patients with and without HT.ResultsThe incidence of HT in ischemic stroke with AF was 22.6%. Univariate analysis established that old age, hypertension, diabetes mellitus, anticoagulant medications, NIHSS, cerebral microbleeds (CMB), superficial siderosis (SS) and size of infarction were significantly more frequent with HT. Multivariable logistic regression analysis demonstrated that old age [odds ratio (OR): 1.05, confidence interval (CI) 1.01–1.09], size of infarction (OR: 2.57, CI 1.06–6.27) and CMB ≥ 10 (OR: 4.68, CI 1.71–12.84) were significantly associated with the risk of HT.ConclusionsOlder age, larger infarction size, and CMB ≥ 10 were risk factors significantly associated with HT.

【 授权许可】

CC BY   
© Egyptian Society of Neurology, Psychiatry, and Neurosurgery 2023