Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism

Journal of Nanobiotechnology

Research

Jian-qing Wu¹  Chuan-dong Zhu²  Jin-long Tong³  Han-Feng Xu³  Quan-an Zhang³  Qin Zheng³  Li-xue Wang³  Yuan Wan⁴ 

[1] Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu, People’s Republic of China;Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu, People’s Republic of China;Department of Oncology, The Second Hospital Affiliated of Southeast University, 210003, Nanjing, Jiangsu, People’s Republic of China;Department of Oncology, The Second Hospital Affiliated of Southeast University, 210003, Nanjing, Jiangsu, People’s Republic of China;Department of Oncology, The Second Hospital Affiliated of Southeast University, 210003, Nanjing, Jiangsu, People’s Republic of China;PMR Institute, 201203, Shanghai, People’s Republic of China;PerMed Biomedical Co. Ltd., 575 Bibo Road, 201203, Shanghai, People’s Republic of China;

关键词: Gold nanoparticles;    Galactose;    Polyethylene glycol;    γ-H2AX;    Radiosensitization;    Hepatocellular carcinoma;   

DOI  :  10.1186/s12951-015-0129-x

 received in 2015-04-28, accepted in 2015-09-25,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundBiocompatible gold nanoparticles (GNPs) are potentially practical and efficient agents in cancer radiotherapy applications. In this study, we demonstrated that GNPs can significantly modulate irradiation response of hepatocellular carcinoma cells in vitro and investigated the underlying mechanisms. We co-grafted galactose (GAL) targeting hepatocyte specific asialoglycoprotein receptor and Polyethylene Glycol (PEG) onto GNPs surfaces to increase GNPs targeting specificity and stability.ResultsThis novel GAL-PEG-GNPs and bare GNPs show similar appearance and cytotoxicity profiles, while more GAL-PEG-GNPs can be effectively uptaken and could enhance cancer cell killing.ConclusionGAL-PEG-GNPs have better radiosensitization to HepG2. The sensitization mechanism of GAL-PEG-GNPs is related to the apoptotic gene process activated by generation of a large amount of free radicals induced by GNPs.

【 授权许可】

CC BY   
© Zhu et al. 2015