Evaluation of health outcomes in osteoarthritis patients after total knee replacement: a two-year follow-up

Health and Quality of Life Outcomes

Research

Hin-Peng Lee¹  Eleanor M Pullenayegum²  Ngai-Nung Lo³  Feng Xie⁴  Ron Goeree⁴  Daria J O'Reilly⁴  Jean-Eric Tarride⁴ 

[1] Centre for Health Services Research, National University of Singapore, Singapore;Department of Community, Occupation, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore;Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, L8 S 4L8, Hamilton, Canada;Centre for Evaluation of Medicine, St. Joseph's Healthcare Hamilton, L8N 1G6, Hamilton, Canada;Department of Orthopaedic Surgery, Singapore General Hospital, 169608, Singapore;Programs for Assessment of Technology in Health, St. Joseph's Healthcare Hamilton, L8P 1H1, Hamilton, Canada;Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, L8 S 4L8, Hamilton, Canada;

关键词: Physical Functioning;    Total Knee Replacement;    Generalize Estimate Equation;    Oxford Knee Score;    Physical Functioning Score;   

DOI  :  10.1186/1477-7525-8-87

 received in 2010-03-05, accepted in 2010-08-19,  发布年份 2010

来源: Springer

【 摘 要 】

ObjectivesTo quantify the improvement in health outcomes in patients after total knee replacement (TKR).MethodsThis was a two-year non-randomized prospective observational study in knee osteoarthritis (OA) patients undergone TKR. Patients were interviewed one week before, six months after, and two years after surgery using a standardized questionnaire including the SF-36, the Oxford Knee Score (OKS), and the Knee Society Clinical Rating Scale (KSS). A generalized estimating equation (GEE) model was used to estimate the magnitudes of the changes with and without the adjustment of age, ethnicity, BMI, and years with OA.ResultsA total of 298 (at baseline), 176 (at six-months), and 111 (at two-years) eligible patients were included in the analyses. All the scores changed significantly over time, with the exception of SF-36 social functioning, vitality, and mental health. With the adjustment of covariates, the magnitude of changes in these scores was similar to those without the adjustment.ConclusionsBoth general and knee-specific physical functioning had been significantly improved after TKR, while other health domains have not been substantially improved after the surgery.

【 授权许可】

CC BY   
© Xie et al; licensee BioMed Central Ltd. 2010