Animal study assessing safety of an acoustic coupling fluid that holds the potential to avoid surgically induced artifacts in 3D ultrasound guided operations

BMC Medical Imaging

Research Article

Arve Jørgensen¹  Petter Aadahl¹  Sverre H Torp²  Ralf-Peter Michler³  Asgeir S Jakola⁴  Ole Solheim⁵  Geirmund Unsgård⁵  Lisa M Sagberg⁶  Tormod Selbekk⁷ 

[1] Department of Diagnostic Imaging, St.Olavs University Hospital, Trondheim, Norway;Department of Laboratory Medicine, Children’s and Women’s Health, Norwegian University of Science and Technology, Trondheim, Norway;Department of Pathology and Medical Genetics, St.Olavs University Hospital, Trondheim, Norway;Department of Neurology and Clinical Neurophysiology, St.Olavs University Hospital, Trondheim, Norway;Department of Neurosurgery, St.Olavs University Hospital, N-7006, Trondheim, Norway;MI Lab, Norwegian University of Science and Technology, Trondheim, Norway;Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway;National Competence Centre for Ultrasound and Image-guided Therapy, Trondheim, Norway;Department of Neurosurgery, St.Olavs University Hospital, N-7006, Trondheim, Norway;National Competence Centre for Ultrasound and Image-guided Therapy, Trondheim, Norway;National Competence Centre for Ultrasound and Image-guided Therapy, Trondheim, Norway;National Competence Centre for Ultrasound and Image-guided Therapy, Trondheim, Norway;Department of Medical Technology, SINTEF, Trondheim, Norway;

关键词: Brain imaging;    Brain tumor;    Intraoperative imaging;    Ultrasound;   

DOI  :  10.1186/1471-2342-14-11

 received in 2013-12-01, accepted in 2014-03-19,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundUse of ultrasound in brain tumor surgery is common. The difference in attenuation between brain and isotonic saline may cause artifacts that degrade the ultrasound images, potentially affecting resection grades and safety. Our research group has developed an acoustic coupling fluid that attenuates ultrasound energy like the normal brain. We aimed to test in animals if the newly developed acoustic coupling fluid may have harmful effects.MethodsEight rats were included for intraparenchymal injection into the brain, and if no adverse reactions were detected, 6 pigs were to be included with injection of the coupling fluid into the subarachnoid space. Animal behavior, EEG registrations, histopathology and immunohistochemistry were used in assessment.ResultsIn total, 14 animals were included, 8 rats and 6 pigs. We did not detect any clinical adverse effects, seizure activity on EEG or histopathological signs of tissue damage.ConclusionThe novel acoustic coupling fluid intended for brain tumor surgery appears safe in rats and pigs under the tested circumstances.

【 授权许可】

CC BY   
© Jakola et al.; licensee BioMed Central Ltd. 2014