Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

Thrombosis Journal

Research

Takeshi Matsumoto¹  Masaaki Ito²  Norikazu Yamada²  Kaname Nakatani³  Makoto Ikejiri³  Naoki Fujimoto⁴  Hideo Wada⁵  Shine Tone⁶  Hiroki Wakabayashi⁶  Masahiro Hasegawa⁶  Akihiro Sudo⁶ 

[1] Department of Blood Transfusion Service, Mie University Graduate School of Medicine, Tsu, Japan;Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan;Department of Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan;Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan;Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan;Department of Laboratory Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Mie-ken 514-8507, Tsu -City, Japan;Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan;

关键词: Deep vein thrombosis (DVT);    Anti-Xa activity;    DOAC;    Prophylaxis;    Orthopedic surgery;   

DOI  :  10.1186/s12959-017-0150-4

 received in 2017-08-08, accepted in 2017-09-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMeasurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).MethodsThe anti-Xa activity was measured one hour after edoxaban intake using 3 different assays in 200 patients after major orthopedic surgery.ResultsThe anti-Xa activities on Day 8 were significantly higher than those on Day 4 and those on Day 4 were significantly higher than those on Day 1. The anti-Xa activities in two assays closely correlated with each other, but the other anti-Xa assay did not correlated with other two assays. The anti-Xa activities as detected in the three Xa assays were significantly higher in the patients without deep vein thrombosis (DVT) than in those with DVT on Day 4. Additionally, there were no significant differences in the anti-Xa activities of assays A, B and C between patients with and without massive bleeding (MB) on Days 1, 4, 8 and 15.ConclusionThe results of this study suggest that anti-Xa level could be predictive of the risk of VTE, but not of the risk of massive bleeding.

【 授权许可】

CC BY   
© The Author(s). 2017