Validation of T2* in-line analysis for tissue iron quantification at 1.5 T

Journal of Cardiovascular Magnetic Resonance

Research

Peter Drivas¹  Cemil Izgi¹  Karen Symmonds¹  Rick Wage¹  Mohammed H. Alam²  Gillian C. Smith²  Dominique Auger²  David Firmin²  Dudley J. Pennell²  Taigang He³  Lisa Anderson⁴  Andreas Greiser⁵  Bruce S. Spottiswoode⁶ 

[1] Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK;Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK;National Heart and Lung Institute, Imperial College, London, UK;Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, Sydney Street, SW3 6NP, London, UK;National Heart and Lung Institute, Imperial College, London, UK;Cardiovascular Science Research Center, St George’s, University of London, London, UK;Cardiovascular Science Research Center, St George’s, University of London, London, UK;Siemens AG Healthcare, Erlangen, Germany;Siemens Medical Solutions USA Inc, Malvern, PA, USA;

关键词: CMR;    T2*;    In-line processing;    Heart;    Liver;    Iron overload;   

DOI  :  10.1186/s12968-016-0243-4

 received in 2015-12-22, accepted in 2016-04-20,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThere is a need for improved worldwide access to tissue iron quantification using T2* cardiovascular magnetic resonance (CMR). One route to facilitate this would be simple in-line T2* analysis widely available on MR scanners. We therefore compared our clinically validated and established T2* method at Royal Brompton Hospital (RBH T2*) against a novel work-in-progress (WIP) sequence with in-line T2* measurement from Siemens (WIP T2*).MethodsHealthy volunteers (n = 22) and patients with iron overload (n = 78) were recruited (53 males, median age 34 years). A 1.5 T study (Magnetom Avanto, Siemens) was performed on all subjects. The same mid-ventricular short axis cardiac slice and transaxial slice through the liver were used to acquire both RBH T2* images and WIP T2* maps for each participant. Cardiac white blood (WB) and black blood (BB) sequences were acquired. Intraobserver, interobserver and interstudy reproducibility were measured on the same data from a subset of 20 participants.ResultsLiver T2* values ranged from 0.8 to 35.7 ms (median 5.1 ms) and cardiac T2* values from 6.0 to 52.3 ms (median 31 ms). The coefficient of variance (CoV) values for direct comparison of T2* values by RBH and WIP were 6.1–7.8 % across techniques. Accurate delineation of the septum was difficult on some WIP T2* maps due to artefacts. The inability to manually correct for noise by truncation of erroneous later echo times led to some overestimation of T2* using WIP T2* compared with the RBH T2*. Reproducibility CoV results for RBH T2* ranged from 1.5 to 5.7 % which were better than the reproducibility of WIP T2* values of 4.1–16.6 %.ConclusionsIron estimation using the T2* CMR sequence in combination with Siemens’ in-line data processing is generally satisfactory and may help facilitate global access to tissue iron assessment. The current automated T2* map technique is less good for tissue iron assessment with noisy data at low T2* values.

【 授权许可】

CC BY   
© Alam et al. 2016