Low serum magnesium concentrations are associated with a high prevalence of premature ventricular complexes in obese adults with type 2 diabetes

Cardiovascular Diabetology

Original Investigation

Ronald J Elin¹  Yiqing Song²  Eric Dewailly³  Paul Poirier⁴  Liana C Del Gobbo⁵  Grace M Egeland⁵ 

[1] Department of Pathology and Laboratory Medicine, University of Louisville, 40292, Louisville, Kentucky, USA;Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave, 02215, Boston, Massachusetts, USA;Public Health Research Unit, CHUL Research Center, Centre Hospitalier, Universitaire de Quebec Sainte-Foy, G1V 5B3, Quebec City, Quebec, Canada;Quebec Heart and Lung Institute, Sainte-Foy, Quebec, Canada;School of Dietetics & Human Nutrition, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, H9X 3V9, Quebec, Canada;

关键词: Magnesium;    Hypomagnesemia;    Premature ventricular complexes;    Premature ventricular beats;    Ectopic beats;    Arrhythmia;    Type 2 diabetes;   

DOI  :  10.1186/1475-2840-11-23

 received in 2012-02-09, accepted in 2012-03-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPremature ventricular complexes (PVC) predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium (Mg) depletion studies in adults. We thus hypothesized that serum magnesium (sMg) concentrations are inversely associated with the prevalence of PVC in adults at high cardiovascular risk.MethodsAnthropometric, demographic and lifestyle characteristics were assessed in 750 Cree adults, aged > 18 yrs, who participated in an age-stratified, cross-sectional health survey in Quebec, Canada. Holter electrocardiograms recorded heart rate variability and cardiac arrhythmias for two consecutive hours. Multivariate logistic regression was used to evaluate the associations between sMg and PVC.ResultsPVC prevalence in adults with hypomagnesemia (sMg ≤ 0.70 mmol/L) was more than twice that of adults without hypomagnesemia (50% vs. 21%, p = 0.015); results were similar when adults with cardiovascular disease history were excluded. All hypomagnesemic adults with PVC had type 2 diabetes (T2DM). Prevalence of PVC declined across the sMg concentration gradient in adults with T2DM only (p < 0.001 for linear trend). In multivariate logistic regressions adjusted for age, sex, community, body mass index, smoking, physical activity, alcohol consumption, kidney disease, antihypertensive and cholesterol lowering drug use, and blood docosahexaenoic acid concentrations, the odds ratio of PVC among T2DM subjects with sMg > 0.70 mmol/L was 0.24 (95% CI: 0.06-0.98) p = 0.046 compared to those with sMg ≤ 0.70 mmol/L.ConclusionssMg concentrations were inversely associated with the prevalence of PVC in patients with T2DM in a dose response manner, indicating that suboptimal sMg may be a contributor to arrhythmias among patients with T2DM.

【 授权许可】

CC BY   
© Del Gobbo et al; licensee BioMed Central Ltd. 2012