Shedding light on local kinase activation

BMC Biology

Opinion

Alexandra C Newton¹  John D Scott² 

[1] Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA;Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Ave. NE, 98195, Seattle, WA, USA;

关键词: Lipid Raft;    Fluorescence Resonance Energy Transfer;    Rolipram;    Fluorescence Resonance Energy Transfer Pair;    Luminescence Resonance Energy Transfer;   

DOI  :  10.1186/1741-7007-10-61

 received in 2012-05-10, accepted in 2012-07-16,  发布年份 2012

来源: Springer

【 摘 要 】

Phosphorylation is the predominant language of cell signaling. And, as with any common language, an abundance of dialects has evolved to convey complex information. We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell.

【 授权许可】

CC BY   
© Scott and Newton; licensee BioMed Central Ltd. 2012