The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects

Lipids in Health and Disease

Research

Fatih Davran¹  Halide S Akbas¹  Didem Kemaloglu²  Serkan Koc²  Ibrahim Demir²  Gultekin Suleymanlar³  Sebahat Basyigit³  Inci Suleymanlar⁴ 

[1] Akdeniz University Faculty of Medicine, Department of Biochemistry, Antalya, Turkey;Akdeniz University Faculty of Medicine, Department of Cardiology, Antalya, Turkey;Akdeniz University Faculty of Medicine, Department of Medicine, Antalya, Turkey;Akdeniz University Faculty of Medicine, Division of Gastroenterology, Antalya, Turkey;

关键词: Pylorus Infection;    Carotid Intima Media Thickness;    Paraoxon;    PON1 Activity;    Negative Subject;   

DOI  :  10.1186/1476-511X-9-92

 received in 2010-07-09, accepted in 2010-08-30,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori) infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C) has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1) is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects.MethodsThirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries.ResultsWe found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014). We found that PON1 activities were significantly lower in H. pylori positive subjects compared with negative subjects. No significantly correlation was observed between PON1 and CIMT values.ConclusionsThere is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms.

【 授权许可】

CC BY   
© Akbas et al; licensee BioMed Central Ltd. 2010