Parma consensus statement on metabolic disruptors

Environmental Health

Commentary

Jérôme Ruzzin¹  R. Thomas Zoeller²  Gemma Calamandrei³  Graziano Ceresini⁴  Bruce Blumberg⁵  Michele La Merrill⁶  Laura Rizzir⁷  Riccardo Volpi⁸  Valentina Pomatto⁹  Patrizia Bovolin⁹  Silvia Paterlini^1,10  Giancarlo Panzica^1,10  Laura Gioiosa^1,11  Paola Palanza^1,11  Susan C. Nagel^1,12  Maria E. Street^1,13  Luisa Montanini^1,14  Giorgio Sartor^1,15  Juliette Legler^1,16  Frederick S. vom Saal^1,17  Christopher Kassotis^1,17  Alexander Suvorov^1,17  Thaddeus T. Schug^1,18  Jerrold J. Heindel^1,18  Stefano Parmigiani^1,19  Alberto Mantovani^2,20  Elena Fabbri^2,21  Barbara A. Cohn^2,22  Michelle A. Mendez^2,23  Ronit Machtinger^2,24  Laura Molteni^2,25 

[1] Department of Biology, University of Bergen, Bergen, Norway;Department of Biology, University of Massachusetts, Amherst, MA, USA;Department of Cell Biology and Neurosciences, Insituto Superiore di Sanita, Rome, Italy;Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy;Department of Developmental and Cell Biology, University of California, Irvine, CA, USA;Department of Environmental Toxicology, University of California, Davis, CA, USA;Department of Health Sciences, University of Milano-Bicocca, Monza, Italy;Department of Internal Medicine, University of Parma, Parma, Italy;Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy;Department of Neuroscience and Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Turin, Italy;Department of Neuroscience, University of Parma, Parma, Italy;Department of Obstetrics, Gynecology and Women’s Health, University of Missouri, Columbia, MO, USA;Department of Pediatrics, University Hospital, Parma, Italy;Department of Pediatrics, University of Parma, Parma, Italy;Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy;Department of Toxicology and Environmental Health, VU University Amsterdam, Amsterdam, Netherlands;Division of Biological Sciences, University of Missouri, Columbia, MO, USA;Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA;Faculty of Medicine, University of Parma, Parma, Italy;Instituto Superiore di Sanita, Rome, Italy;Interdepartment Center for Environmental Science Research, University of Bologna, Ravenna, Italy;Public Health Institute, Berkeley, CA, USA;School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;Sheba Medical Center and Tel-Aviv University, Tel –Aviv, Israel;University of Milano-Bicocca, Monza, Italy;

关键词: Metabolic disruptor;    Obesogen;    Obesity;    Diabetes;    Metabolic syndrome;    Developmental Programming;   

DOI  :  10.1186/s12940-015-0042-7

 received in 2015-04-07, accepted in 2015-06-03,  发布年份 2015

来源: Springer

【 摘 要 】

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16–18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as “metabolic disruptors”, in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.

【 授权许可】

CC BY   
© Heindel et al. 2015