Identification of the causal relationship between sleep quality, insomnia, and oral ulcers

BMC Oral Health

Research

Xuefeng Zhang¹  Jiongke Wang²  Qianxi Liu²  Tiannan Liu²  Xin Zeng² 

[1] Emergency Department, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Chinese Academy of Medical Sciences, Sichuan University, 610041, Chengdu, Sichuan, P. R. China;State Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences, Sichuan University, 3rd Section of Ren Min Nan Rd, 610041, Chengdu, Sichuan, P. R. China;

关键词: Sleep duration;    Insomnia;    Mouth ulcer;    Mendelian randomization;    Genetic correlation;   

DOI  :  10.1186/s12903-023-03417-w

 received in 2023-07-05, accepted in 2023-09-14,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMultiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases.MethodsWe utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652).ResultsOur results revealed a negative genetic correlation between sleep duration and mouth ulcer (genetic correlation: -0.09, P = 0.007), while a positive genetic correlation between insomnia and mouth ulcer was observed (genetic correlation: 0.18, P = 2.51E-06). Furthermore, we demonstrated that longer sleep duration is significantly associated with a reduced risk of mouth ulcers (OR: 0.67, 95% CI: 0.54–0.83, P = 2.84E-04), whereas insomnia is nominally associated with an increased risk of mouth ulcers (OR: 1.40, 95% CI: 1.01–1.95, P = 0.044). In contrast, no significant association was detected between sleep quality and periodontal disease or oral cavity cancer.ConclusionsThis work provides robust evidence to support the notion that enhanced sleep quality may confer a decreased risk of oral ulcers, thereby bearing considerable clinical relevance.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 1