Relationship between hypoparathyroidism and the number of parathyroid glands preserved during thyroidectomy

World Journal of Surgical Oncology

Research

You Hern Ahn¹  Yong Bae Ji²  Joo Hwan Jung²  Hyun Jung Min²  Kyung Tae²  Chang Myeon Song² 

[1] Department of Internal Medicine, College of Medicine, Hanyang University, 222 Wangsimniro, 133-792, Seongdong-Gu, Seoul, South Korea;Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimniro, 133-792, Seongdong-Gu, Seoul, South Korea;

关键词: Thyroidectomy;    Parathyroid;    Thyroid cancer;    Hypoparathyroidism;    Hypocalcemia;   

DOI  :  10.1186/1477-7819-12-200

 received in 2013-10-02, accepted in 2014-06-29,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe relationship between the number of parathyroid glands preserved and hypoparathyroidism is not well understood. We sought to determine the number of parathyroid glands that need to be preserved to prevent hypoparathyroidism.MethodsWe analyzed 454 patients who underwent total thyroidectomy for papillary thyroid carcinoma. We analyzed the frequency of hypoparathyroidism according to the number of parathyroid glands preserved.ResultsIncidental parathyroidectomy occurred in 19.8% of the patients; one parathyroid gland in 17.6%, two in 1.5%, and three in 0.7%. Transient hypoparathyroidism was increased when incidental parathyroidectomy occurred (odds ratio 1.83, 95% confidence interval 1.04 to 3.23, P = 0.036) on multivariate regression analysis, but was not influenced by the actual number of parathyroid glands removed. There was no relationship between the number of parathyroid glands preserved and permanent hypoparathyroidism (P = 0.147).ConclusionsPreservation of all parathyroid glands decreases transient hypoparathyroidism compared with when three or fewer glands are preserved, but does not affect permanent hypoparathyroidism. During total thyroidectomy, preserving at least one parathyroid gland with an intact blood supply appears to be sufficient to prevent permanent hypoparathyroidism when autotransplantation is not performed.

【 授权许可】

Unknown   
© Song et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.