Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case–control study

Environmental Health

Research

Yuan Lin¹  Dezhi Mu²  Jun Li³  Xinlin Chen⁴  Shengli Li⁵  Fengzhi You⁶  Nana Li⁷  Xiaohong Li⁸  Kui Deng⁸  Yanping Wang⁸  Jun Zhu⁹  Zhen Liu⁹ 

[1] Department of Obstetrics; Gynecology, Fujian provincial Maternal and Child Healthcare Hospital, Fuzhou, China;Department of Pediatric, West China Second University Hospital, Sichuan University, Chengdu, China;Department of Ultrasonic Diagnosis, Xijing Hospital, Fourth Military Medical University, Xi’an, China;Department of Ultrasound, Hubei provincial Maternal and Child Healthcare Hospital, Wuhan, China;Department of Ultrasound, Shenzhen Maternity; Child Healthcare Hospital, Affiliated to Southern Medical University, Shenzhen, China;Department of women sanitation, Henan provincial Maternal and Child Healthcare Hospital, Zhengzhou, China;Laboratory of Molecular Epidemiology for birth defect, West China Institute of Women and Children's Health, Sichuan University, Chengdu, China;National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China;National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China;Laboratory of Molecular Epidemiology for birth defect, West China Institute of Women and Children's Health, Sichuan University, Chengdu, China;

关键词: Air pollution;    Congenital heart disease;    Pregnancy;    Reproductive health;    Housing;    Indoor air;   

DOI  :  10.1186/1476-069X-12-25

 received in 2012-11-13, accepted in 2013-03-19,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundCongenital heart disease (CHD) is one of the most prevalent birth defects. Housing renovations are a newly recognized source of indoor environmental pollution that is detrimental to health. A growing body of research suggests that maternal occupational exposure to renovation materials may be associated with an increased risk of giving birth to fetuses with CHD. However, the effect of indoor housing renovation exposure on CHD occurrence has not been reported.MethodsA multi-hospital case–control study was designed to investigate the association between maternal periconceptional housing renovation exposure and the risk of CHD for offspring. In total, 346 cases and 408 controls were enrolled in this study from four hospitals in China. Exposure information was based on a questionnaire given to women during pregnancy. The association between housing renovation exposure and CHD occurrence was assessed by estimating odds ratios (OR) with logistic regression models adjusted for potential confounders.ResultsThe risk for CHD in offspring was significantly associated with maternal exposure to housing renovations (AOR: 1.89, 95% CI: 1.29-2.77). There were similar risks for cardiac defects with or without extra-cardiac malformation (AOR of 2.65 and 1.76, respectively). Maternal housing renovation exposure may increase the fetus’ risk of suffering from conotruncal defect or anomalous venous return. There were significant risks for cardiac defects if the pregnant woman moved into a new house within one month after decoration at either 3 months before pregnancy (AOR: 2.38, 95% CI: 1.03 to 5.48) or during first trimester (AOR: 4.00, 95% CI: 1.62 to 9.86).ConclusionsMaternal exposure to housing renovations may have an increased risk of giving birth to fetuses with some selected types of CHD. This relationship was stronger for women who moved into a newly decorated house. However, considering the limited number of subjects and the problem of multiple exposures, more research is needed to clarify the effects seen here.

【 授权许可】

Unknown   
© Liu et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.