Impaired plasma lipid profiles in acute hepatitis

Lipids in Health and Disease

Research

Ning Xu¹  Libo Luo²  Yongzhong Wang³  Xiangke Pu⁴ 

[1] Department of Clinical Chemistry and Pharmacology, University Hospital of Lund, S-22185, Lund, Sweden;First People's Hospital of Changzhou, 213003, Jiangsu, China;Third People's Hospital of Changzhou, 213001, Jiangsu, China;Third People's Hospital of Changzhou, 213001, Jiangsu, China;School of Radiology and Public Health, Soochow University, 215123, Jiangsu, China;

关键词: High Density Lipoprotein Cholesterol;    Acute Hepatitis;    Acute Viral Hepatitis;    Plasma Lipid Profile;    Endogenous Lipid;   

DOI  :  10.1186/1476-511X-9-5

 received in 2009-11-16, accepted in 2010-01-23,  发布年份 2010

来源: Springer

【 摘 要 】

The present study examined plasma lipid profiles in thirty patients suffered from acute viral hepatitis. Patients' blood samples were collected at both the debut and recovery of diseases. Thirty sex and age matched normal subjects were included as controls. Plasma total triglycerides (TG), total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB), lipoprotein (a) (Lp(a)), blood coagulation status including prothrombin complex activity and activated partial tromboplastin time (APTT), and hepatic functions were determined by the automatic biochemical analytical instrument. It demonstrated that plasma levels of total cholesterol, HDL-C and apoAI were significantly lower in the patients at the acute phase of hepatitis than those in normal subjects, whereas plasma levels of TG and LDL-C were obviously higher in the patients than in normal subjects (P < 0.05). Moreover, we demonstrated that patients' plasma levels of total cholesterol, LDL-C, HDL-C and apoAI were lower at the active phase of the diseases than at the recovering phase, which indicating that acute liver damage could significant influence lipid metabolism in vivo. No pathological changes of blood coagulation status occurred in these patients during the study as all selected patients had moderate hepatitis. It may conclude that examinations of plasma lipid profile could be considered as a clinical index to reflect liver damage in the active phase of hepatitis.

【 授权许可】

Unknown   
© Luo et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.