Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens

BMC Proceedings

Proceedings

Hyun S Lillehoj¹  Sung H Lee¹  Duk K Kim¹  David M Bravo² 

[1] Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture-Agricultural Research Service, 20705, Beltsville, MD, USA;Pancosma S.A., Voie-des-Traz 6, CH-1218, Le Grand Saconnex, Geneva, Switzerland;

关键词: Ingenuity Pathway Analysis;    Broiler Chicken;    Coccidiosis;    Percoll Density Gradient Centrifugation;    Linoleic Acid Metabolism;   

DOI  :  10.1186/1753-6561-5-S4-S34

来源: Springer

【 摘 要 】

BackgroundThe present study was conducted to investigate the effects of dietary plant-derived phytonutrients, carvacrol, cinnamaldehyde and Capsicum oleoresin, on the translational regulation of genes associated with immunology, physiology and metabolism using high-throughput microarray analysis and in vivo disease challenge model of avian coccidiosis.MethodsIn this study, we used nutrigenomics technology to investigate the molecular and genetic mechanisms of dietary modulation of host innate immunity and metabolism by three phytonutrients. To validate their immunomodulatory effects in a disease model, young broiler chickens fed a standard diet supplemented with three phytochemicals (carvacrol, cinnamaldehyde, and Capsicum oleoresin) from one day post-hatch were orally challenged with E. acervulina. The body weight gain and fecal oocyst production were used to evaluate coccidiosis disease parameters.ResultsAnalysis of global gene expression profiles of intestinal tissues from phytonutrient-fed birds indicated that Capsicum oleoresin induced the most gene changes compared to the control group where many of these genes were associated with those of metabolism and immunity. The most reliable network induced by dietary cinnamaldehyde treatment was related with the functions of antigen presentation, humoral immune response, and inflammatory disease. Furthermore, dietary supplementation with these phytonutrients significantly protected broiler chickens against live coccidiosis challenge infection based on body weight and parasite fecundity.ConclusionsThe results of this study provide clear evidence to support the idea that plant-derived phytochemicals possess immune-enhancing properties in chickens and these new findings create a new possibility to develop effective drug-free alternative strategies for disease control for poultry infectious diseases.

【 授权许可】

CC BY   
© Lillehoj et al; licensee BioMed Central Ltd. 2011