Designing verbal autopsy studies

Population Health Metrics

Research

Kenji Shibuya¹  Ying Lu²  Gary King³ 

[1] Department of Global Health Policy, Graduate School of Medicine, University of Tokyo, Japan;Department of Humanities and Social Sciences in the Professions, Steinhardt School of Culture, Education and Human Development, New York University, USA;Institute for Quantitative Social Science, Harvard University, 02138, Cambridge, MA, USA;

关键词: Mean Square Error;    Verbal Autopsy;    Symptom Profile;    Random Measurement Error;    Individual Death;   

DOI  :  10.1186/1478-7954-8-19

 received in 2010-01-08, accepted in 2010-06-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundVerbal autopsy analyses are widely used for estimating cause-specific mortality rates (CSMR) in the vast majority of the world without high-quality medical death registration. Verbal autopsies -- survey interviews with the caretakers of imminent decedents -- stand in for medical examinations or physical autopsies, which are infeasible or culturally prohibited.Methods and FindingsWe introduce methods, simulations, and interpretations that can improve the design of automated, data-derived estimates of CSMRs, building on a new approach by King and Lu (2008). Our results generate advice for choosing symptom questions and sample sizes that is easier to satisfy than existing practices. For example, most prior effort has been devoted to searching for symptoms with high sensitivity and specificity, which has rarely if ever succeeded with multiple causes of death. In contrast, our approach makes this search irrelevant because it can produce unbiased estimates even with symptoms that have very low sensitivity and specificity. In addition, the new method is optimized for survey questions caretakers can easily answer rather than questions physicians would ask themselves. We also offer an automated method of weeding out biased symptom questions and advice on how to choose the number of causes of death, symptom questions to ask, and observations to collect, among others.ConclusionsWith the advice offered here, researchers should be able to design verbal autopsy surveys and conduct analyses with greatly reduced statistical biases and research costs.

【 授权许可】

CC BY   
© King et al; licensee BioMed Central Ltd. 2010