Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress

BMC Neuroscience

Research Article

Younghyurk Lee¹  Dong Hoon Lee¹  Gyeong Jae Cho¹  Gyeongwha Kim¹  Hyeonwi Son¹  Gu Seob Roh¹  Sang Soo Kang¹  Soonwoong Jung¹  Wan Sung Choi¹  Hyun Joon Kim¹ 

[1] Department of Anatomy and Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction School of Medice, Gyeongsang National University, 92 Chilam-dong, 660-751, Jinju, South Korea;

关键词: Gene Expression Change;    Immobility Duration;    Force Swim Test;    Stressed Group;    Sucrose Preference;   

DOI  :  10.1186/1471-2202-13-58

 received in 2012-02-29, accepted in 2012-06-06,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe amygdala plays an essential role in controlling emotional behaviors and has numerous connections to other brain regions. The functional role of the amygdala has been highlighted by various studies of stress-induced behavioral changes. Here we investigated gene expression changes in the amygdala in the chronic immobilization stress (CIS)-induced depression model.ResultsEight genes were decreased in the amygdala of CIS mice, including genes for neurotrophic factors and extracellular matrix proteins. Among these, osteoglycin, fibromodulin, insulin-like growth factor 2 (Igf2), and insulin-like growth factor binding protein 2 (Igfbp2) were further analyzed for histological expression changes. The expression of osteoglycin and fibromodulin simultaneously decreased in the medial, basolateral, and central amygdala regions. However, Igf2 and Igfbp2 decreased specifically in the central nucleus of the amygdala. Interestingly, this decrease was found only in the amygdala of mice showing higher immobility, but not in mice displaying lower immobility, although the CIS regimen was the same for both groups.ConclusionsThese results suggest that the responsiveness of the amygdala may play a role in the sensitivity of CIS-induced behavioral changes in mice.

【 授权许可】

Unknown   
© Jung et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.