Sex and ethnic/racial-specific risk factors for gallbladder disease

BMC Gastroenterology

Research Article

James Buxbaum¹  Daniel Stram²  Neal Tambe²  Christopher Haiman³  Veronica Wendy Setiawan³  Wendy Cozen⁴  Jane C. Figueiredo⁵  Lynne Wilkens⁶  Loic Le Marchand⁶  Jacqueline Porcel⁷ 

[1] Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA;Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA;Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA;Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA;Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;

关键词: Gallbladder;    Stones;    Cholecystectomy;    Ethnicity/race;   

DOI  :  10.1186/s12876-017-0678-6

 received in 2016-06-20, accepted in 2017-11-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGallbladder disease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations.MethodsWe performed a prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Native Hawaiian (n = 6942) and Latino (n = 39,168). GBD cases were identified using Medicare and California hospital discharge files (1993–2012) and self-completed questionnaires. We used exposure information on the baseline questionnaire to identify exposures of interest. Associations were estimated by hazard ratios and 95% confidence intervals using Cox models adjusted for confounders.ResultAfter a median 10.7 years of follow-up, there were 13,437 GBD cases. BMI over 25 kg/m2, diabetes, past and current smoking, red meat consumption, saturated fat and cholesterol were significant risk factors across ethnic/racial populations (p-trends < 0.01). Protective factors included vigorous physical activity, alcohol use, fruits, vegetables and foods rich in dietary fiber (p-trends < 0.01). Carbohydrates were inversely associated with GBD risk only among women and Latinos born in South America/Mexico (p-trend < 0.003). Parity was a significant risk factor among women; post-menopausal hormones use was only associated with an increased risk among White women (estrogen-only: HR = 1.24; 95% CI = 1.07–1.43 and estrogen + progesterone: HR = 1.23; 95% CI = 1.06–1.42).ConclusionOverall, dietary, reproductive and obesity-related factors are strong risk factors for GBD affecting men and women of different ethnicities/races; however some risk factors appear stronger in women and certain ethnic groups.

【 授权许可】

CC BY   
© The Author(s). 2017