Diagnosis of rectal cancer by Tissue Resonance Interaction Method

BMC Gastroenterology

Research Article

Ermanno Leo¹  Elia Poiasina¹  Alberto Vannelli¹  Luigi Battaglia¹ 

[1] Division of General Surgery B, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy;

关键词: Rectal Cancer;    Anal Verge;    Compute Tomographic Colonography;    Neoplastic Lesion;    Rectal Cancer Patient;   

DOI  :  10.1186/1471-230X-10-45

 received in 2009-10-16, accepted in 2010-05-12,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSince population screening has the potential to reduce mortality from rectal cancer (RC), novel methods with improved cost-effectiveness warrant consideration. In a previous pilot study, we found that the rapid, inexpensive and non-invasive electromagnetic detection of RC is a highly specific and sensitive technique. The aim of the present prospective study was to evaluate the prediction accuracy of electromagnetic detection of RC.Methods304 eligible subjects were consecutively enrolled in our Institute and subjected to electromagnetic detection followed by colonoscopy and histopathologic analysis of biopsies. A putative RC carrier status was attributed to subjects showing an electromagnetic signal < 50 units (U).ResultsRC patients showed a significantly lower electromagnetic signal (40.9 ± 0.9 U; mean ± S.E.) than did non-RC subjects (79.2 ± 1.4 U; P < 2.2e-16). At a threshold < 50 U, electromagnetic detection identified 103 putative patients, whereas colonoscopy detected 108 patients, with an overlap of 91 patients between the two methods. The 15.7% false-negative rate by electromagnetic detection was brought to zero by raising the threshold value to 70 U; on the other hand, such a threshold increased the false-positive rate to 30%.ConclusionElectromagnetic detection of RC at a signal threshold < 70 U appears to eliminate false-negative results. Although colonoscopy would still be required in examining the false-positives associated with the < 70 U electromagnetic threshold, the need for this method would be reduced. Thus, electromagnetic detection represents a new accurate, rapid, simple, and inexpensive tool for early detection of RC that merits testing in large population-based programs.

【 授权许可】

CC BY   
© Vannelli et al; licensee BioMed Central Ltd. 2010