Cellular senescence in skeletal disease: mechanisms and treatment

Cellular & Molecular Biology Letters

Mini Review

Mimi Chen¹  Huilin Yang²  Qiaoli Gu²  Fan He²  Xu He²  Wei Hu²  Qin Shi³  Yuanshu Zhang⁴  Yicheng Ding⁵ 

[1] Department of Orthopedics, Children Hospital of Soochow University, No. 92 Zhongnan Street, 215000, Suzhou, Jiangsu, People’s Republic of China;Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, 215031, Suzhou, Jiangsu, People’s Republic of China;Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, 215031, Suzhou, Jiangsu, People’s Republic of China;Department of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, 214026, Wuxi, Jiangsu, People’s Republic of China;Department of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, 214026, Wuxi, Jiangsu, People’s Republic of China;Xuzhou Medical University, 209 Copper Mountain Road, 221004, Xuzhou, People’s Republic of China;

关键词: Cellular senescence;    Chronic inflammation;    Age-related orthopaedic diseases;    Signalling pathways;    Bone marrow;   

DOI  :  10.1186/s11658-023-00501-5

 received in 2023-05-19, accepted in 2023-10-12,  发布年份 2023

来源: Springer

【 摘 要 】

The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endocrine organ. With aging, the balance of bone homeostasis is disrupted, leading to bone loss and degenerative diseases, such as osteoporosis, osteoarthritis, and intervertebral disc degeneration. Skeletal diseases have a profound impact on the motor and cognitive abilities of the elderly, thus creating a major challenge for both global health and the economy. Cellular senescence is caused by various genotoxic stressors and results in permanent cell cycle arrest, which is considered to be the underlying mechanism of aging. During aging, senescent cells (SnCs) tend to aggregate in the bone and trigger chronic inflammation by releasing senescence-associated secretory phenotypic factors. Multiple signalling pathways are involved in regulating cellular senescence in bone and bone marrow microenvironments. Targeted SnCs alleviate age-related degenerative diseases. However, the association between senescence and age-related diseases remains unclear. This review summarises the fundamental role of senescence in age-related skeletal diseases, highlights the signalling pathways that mediate senescence, and discusses potential therapeutic strategies for targeting SnCs.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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