Radiation and cancer risk: a continuing challenge for epidemiologists

Environmental Health

Proceedings

Jonathan M Samet¹ 

[1] Department of Preventive Medicine, Keck School of Medicine of USC, USC Institute for Global Health, University of Southern California, 1441 Eastlake Ave. Room 4436, MC 9175, 90089, Los Angeles, CA, USA;

关键词: Radon Concentration;    Underground Miner;    Lung Cancer Risk;    Indoor Radon;    Excess Relative Risk;   

DOI  :  10.1186/1476-069X-10-S1-S4

来源: Springer

【 摘 要 】

This paper provides a perspective on epidemiological research on radiation and cancer, a field that has evolved over its six decade history. The review covers the current framework for assessing radiation risk and persistent questions about the details of these risks: is there a threshold and more generally, what is the shape of the dose-response relationship? How do risks vary over time and with age? What factors modify the risk of radiation? The example of radon progeny and lung cancer is considered as a case study, illustrating the modeling of epidemiological data to derive quantitative models and the coherence of the epidemiological and biological evidence. Finally, the manuscript considers the need for ongoing research, even in the face of research over a 60-year span.

【 授权许可】

CC BY   
© Samet; licensee BioMed Central Ltd. 2011