A childhood-onset intestinal toxemia botulism during chemotherapy for relapsed acute leukemia

Annals of Clinical Microbiology and Antimicrobials

Case Report

Haru Kato¹  Michiko Torio²  Satoshi Akamine²  Yasunari Sakai²  Hisanori Nishio²  Kei Nishiyama²  Momoko Sasazuki²  Noriko Ohyama²  Masafumi Sanefuji²  Kentaro Nakashima²  Shouichi Ohga²  Yoshito Ishizaki²  Shunsuke Kanno²  Yuuki Koga²  Hiroshi Asakura³ 

[1] Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan;Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan;Division of Biomedical Food Research, National Institute of Health Sciences, Tokyo, Japan;

关键词: Intestinal toxemia botulism;    Childhood;    Chemotherapy;    Antibiotics;    Acute leukemia;   

DOI  :  10.1186/s12941-017-0240-y

 received in 2017-04-14, accepted in 2017-09-13,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundBotulism is a potentially fatal infection characterized by progressive muscle weakness, bulbar paralysis, constipation and other autonomic dysfunctions. A recent report suggested that cancer chemotherapy might increase the risk for the intestinal toxemia botulism in both adults and children.Case presentationWe report a 5-year-old boy, who developed general muscle weakness, constipation, ptosis and mydriasis during the third induction therapy for relapsed acute myeloid leukemia. He had recent histories of multiple antibiotic therapy for bacteremia and intake of well water at home. Repeated bacterial cultures identified Clostridium botulinum producing botulinum neurotoxin A. Botulinum toxin A was isolated from his stools at 17, 21, and 23 days after the onset. Symptoms were self-limiting, and were fully recovered without anti-botulinum toxin globulin therapy.ConclusionThis is the second report of a pediatric case with cancer chemotherapy-associated intestinal toxemia botulism. Our case provides further evidence that the immunocompromised status due to anti-cancer treatments increases the risk for the development of botulism at all ages in childhood.

【 授权许可】

CC BY   
© The Author(s) 2017