Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock

Journal of Inflammation

Research

Manisha Loomba¹  James J Yang²  Gordon Jacobsen²  Kant Shah³  Ronny M Otero³  Arturo Suarez³  Anja Jaehne³  Emanuel P Rivers⁴  H Bryant Nguyen⁵  Hemal Parekh⁶ 

[1] Department of Anesthesiology, Henry Ford Hospital, Detroit, MI, USA;Department of Biostatistics and Epidemiology, Henry Ford Hospital, Detroit, MI, USA;Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA;Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA;Department of Surgery, Henry Ford Hospital, Detroit, MI, USA;Department of Emergency Medicine, Loma Linda University, Loma Linda, CA;Department of Internal Medicine, Pulmonary and Critical Care Medicine, Loma Linda University, Loma Linda, CA;Department of Internal Medicine, Pulmonary and Critical Care Medicine, Loma Linda University, Loma Linda, CA;

关键词: Septic Shock;    Severe Sepsis;    Disseminate Intravascular Coagulation;    Tissue Hypoxia;    Septic Shock Patient;   

DOI  :  10.1186/1476-9255-7-6

 received in 2009-09-04, accepted in 2010-01-28,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLactate clearance, a surrogate for the magnitude and duration of global tissue hypoxia, is used diagnostically, therapeutically and prognostically. This study examined the association of early lactate clearance with selected inflammatory, coagulation, apoptosis response biomarkers and organ dysfunction scores in severe sepsis and septic shock.MethodsMeasurements of serum arterial lactate, biomarkers (interleukin-1 receptor antagonist, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, intercellular adhesion molecule-1, high mobility group box-1, D-Dimer and caspase-3), and organ dysfunction scores (Acute Physiology and Chronic Health Evaluation II, Simplified Acute Physiology Score II, Multiple Organ Dysfunction Score, and Sequential Organ Failure Assessment) were obtained in conjunction with a prospective, randomized study examining early goal-directed therapy in severe sepsis and septic shock patients presenting to the emergency department (ED). Lactate clearance was defined as the percent change in lactate levels after six hours from a baseline measurement in the ED.ResultsTwo-hundred and twenty patients, age 65.0 +/- 17.1 years, were examined, with an overall lactate clearance of 35.5 +/- 43.1% and in-hospital mortality rate of 35.0%. Patients were divided into four quartiles of lactate clearance, -24.3 +/- 42.3, 30.1 +/- 7.5, 53.4 +/- 6.6, and 75.1 +/- 7.1%, respectively (p < 0.01). The mean levels of all biomarkers and organ dysfunction scores over 72 hours were significantly lower with higher lactate clearance quartiles (p < 0.01). There was a significant decreased in-hospital, 28-day, and 60-day mortality in the higher lactate clearance quartiles (p < 0.01).ConclusionsEarly lactate clearance as a surrogate for the resolution of global tissue hypoxia is significantly associated with decreased levels of biomarkers, improvement in organ dysfunction and outcome in severe sepsis and septic shock.

【 授权许可】

CC BY   
© Nguyen et al; licensee BioMed Central Ltd. 2010