Revisiting the membrane-centric view of diabetes

Lipids in Health and Disease

Review

Marc Pilon¹ 

[1] Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, Medicinaregatan 9, S-405 30, Göteborg, Sweden;

关键词: PAQR-2;    Membrane fluidity;    Diabetes;    AdipoR1;    AdipoR2;    Phospholipid;    Fatty acids;    Diet;    Lipidomics;   

DOI  :  10.1186/s12944-016-0342-0

 received in 2016-09-06, accepted in 2016-09-20,  发布年份 2016

来源: Springer

【 摘 要 】

Fundamental questions remain unresolved in diabetes: What is the actual mechanism of glucose toxicity? Why is there insulin resistance in type 2 diabetes? Why do diets rich in sugars or saturated fatty acids increase the risk of developing diabetes? Studying the C. elegans homologs of the anti-diabetic adiponectin receptors (AdipoR1 and AdipoR2) has led us to exciting new discoveries and to revisit what may be termed “The Membrane Theory of Diabetes”. We hypothesize that excess saturated fatty acids (obtained through a diet rich in saturated fats or through conversion of sugars into saturated fats via lipogenesis) leads to rigid cellular membranes that in turn impair insulin signalling, glucose uptake and blood circulation, thus creating a vicious cycle that contributes to the development of overt type 2 diabetes. This hypothesis is supported by our own studies in C. elegans and by a wealth of literature concerning membrane composition in diabetics. The purpose of this review is to survey this literature in the light of the new results, and to provide an admittedly membrane-centric view of diabetes.

【 授权许可】

CC BY   
© The Author(s). 2016