Serum trefoil factor 3 is a promising non-invasive biomarker for gastric cancer screening: A monocentric cohort study in China

BMC Gastroenterology

Research Article

Hongna Lu¹  Xie Zhang¹  Lina Wu¹  Zhigang Huang¹  Qiubo Zhang¹  Huaxin Ding²  Danping Wang³ 

[1] Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, 57# Xingning Road, 315000, Ningbo, China;Ningbo Diagnostic Pathology Center, 2# Guanghua Road, 315000, Ningbo, China;Ningbo University, 818# Fenghua Road, Jiangbei District, 315000, Ningbo, China;

关键词: Gastric cancer;    Diagnosis;    Serum trefoil factors;    Pepsinogen;   

DOI  :  10.1186/1471-230X-14-74

 received in 2013-11-22, accepted in 2014-03-24,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test.MethodsPatients with gastric cancer, chronic atrophic gastritis (CAG) or chronic non-atrophic gastritis (CNAG), and healthy people were recruited. Serum concentrations of TFFs, PG I, and PG II, as well as the presence of antibodies against Helicobacter pylori, were measured by enzyme-linked immunosorbent assays (ELISA). Receiver operating characteristics (ROC) were used to compare the predictive powers of the selected factors.ResultsThe serum concentrations of TFF1, TFF2, and TFF3 in the control groups were significantly lower than those in the gastric cancer group with the exception of TFF2 which was elevated in CAG. The area under the ROC curve for TFF3 was greater than that for the PG I/II ratio (0.81 vs 0.78). TFF3 also had a significantly higher predictive power for distinguishing gastric cancer than the PG test (odds ratio: 10.33 vs 2.57). Moreover, combining the serum TFF3 and PG tests for gastric cancer had better predictive power than either alone.ConclusionsSerum TFF3 may be a better predictor of gastric cancer than the PG test, while the combined testing of serum PG and TFF3 could further improve the efficacy of gastric cancer screening.

【 授权许可】

CC BY   
© Huang et al.; licensee BioMed Central Ltd. 2014