Age and sex corrected normal reference values of T1, T2 T2* and ECV in healthy subjects at 3T CMR

Journal of Cardiovascular Magnetic Resonance

Research

Jean-Louis Vanoverschelde¹  Christophe de Meester¹  Clotilde Roy¹  Bernhard L. Gerber¹  Agnès Pasquet¹  Mihaela Amzulescu¹  Alisson Slimani¹  David Vancraeynest¹  Anne-Catherine Pouleur¹ 

[1] Pole of Cardiovascular Research (CARD), Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St. Luc, Université Cathologique, Brussels, Belgium;Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St., Lambert, Belgium;

关键词: T1 mapping;    T2 mapping;    T2* mapping;    Extracellular volume;    3 T;    Normal values;   

DOI  :  10.1186/s12968-017-0371-5

 received in 2017-02-23, accepted in 2017-07-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMyocardial T1, T2 and T2* imaging techniques become increasingly used in clinical practice. While normal values for T1, T2 and T2* times are well established for 1.5 Tesla (T) cardiovascular magnetic resonance (CMR), data for 3T remain scarce. Therefore we sought to determine normal reference values relative to gender and age and day to day reproducibility for native T1, T2, T2* mapping and extracellular volume (ECV) at 3T in healthy subjects.MethodsAfter careful exclusion of cardiovascular abnormality, 75 healthy subjects aged 20 to 90 years old (mean 56 ± 19 years, 47% women) underwent left-ventricular T1 (3-(3)-3-(3)-5 MOLLI)), T2 (8 echo- spin echo-imaging) and T2 * (8 echo gradient echo imaging) mapping at 3T CMR (Philips Ingenia 3T and computation of extracellular volume after administration of 0.2 mmol/kg Gadovist). Inter- and intra-observer reproducibility was estimated by intraclass correlation coefficient (ICC). Day to day reproducibility was assessed in 10 other volunteers.ResultsMean myocardial T1 at 3T was 1122 ± 57 ms, T2 52 ± 6 ms, T2* 24 ± 5 ms and ECV 26.6 ± 3.2%. T1 (1139 ± 37 vs 1109 ± 73 ms, p < 0.05) and ECV (28 ± 3 vs 25 ± 2%, p < 0.001), but not T2 (53 ± 8 vs 51 ± 4, p = NS) were significantly greater in age matched women than in men. T1 (r = 0.40, p < 0.001) and ECV (r = 0.37, p = 0.001) increased, while T2 decreased significantly (r = −0.25, p < 0.05) with increasing age. T2* was not influenced by either gender or age. Intra and inter-observer reproducibility was high (ICC ranging between 0.81-0.99), and day to day coefficient of variation was low (6.2% for T1, 7% for T2, 11% for T2* and 11.5% for ECV).ConclusionsWe provide normal myocardial T2, T2*,T1 and ECV reference values for 3T CMR which are significantly different from those reported at 1.5 Tesla CMR. Myocardial T1 and ECV values are gender and age dependent. Measurement had high inter and intra-observer reproducibility and good day-to-day reproducibility.

【 授权许可】

CC BY   
© The Author(s). 2017