The complexity of bladder cancer: long noncoding RNAs are on the stage

Molecular Cancer

Review

Mo Su¹  Quanan Zhang¹  Jiangdong Wang²  Guangming Lu² 

[1] Department of Oncology, the Second Affiliated Hospital, Southeast University, 210009, Nanjing, Jiangsu, China;Department of Pathology, Laboratory of Molecular Pathology and Molecular Imaging, Jinling Hospital, School of Medicine Nanjing University, 305 Zhong Shan Dong Lu, 210002, Nanjing, China;

关键词: Bladder cancer;    Long noncoding RNAs;    lncRNAs;    Gene regulatory network;   

DOI  :  10.1186/1476-4598-12-101

 received in 2013-06-24, accepted in 2013-08-15,  发布年份 2013

来源: Springer

【 摘 要 】

The mammalian genome encodes thousands of long noncoding RNAs (lncRNAs) and it is increasingly clear that lncRNAs are key regulators of cellular function and development. Gain and/or loss of function studies in cell culture indicate that lncRNAs can regulate gene transcription indirectly through the targeting and recruitment of chromatin-modifying complexes as well as directly at the transcriptional or posttranscriptional levels. LncRNA biology is attracting great attention in cancer research because dysregulated lncRNAs occur in a variety of cancers, placing lncRNAs on the stage of cancer genome research. We briefly describe the latest lncRNA biology and discuss the oncogenic lncRNAs involved in core pathways in bladder cancer and the application of lncRNAs to its diagnosis and targeted treatment. LncRNAs are becoming essential components of the gene regulatory circuitry in the complexity of bladder cancer.

【 授权许可】

Unknown   
© Zhang et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.