Predicting mortality in paraquat poisoning through clinical findings, with a focus on pulmonary and cardiovascular system disorders

Journal of Pharmaceutical Policy and Practice

Research

Preechaya Tajai¹  Akarawat Kornjirakasemsan² 

[1] Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand;Pharmacy Department, Nakornping Hospital, 50180, Chiang Mai, Thailand;

关键词: Paraquat;    Poisoning;    Prediction;    Prognosis;    Mortality;   

DOI  :  10.1186/s40545-023-00635-z

 received in 2023-07-20, accepted in 2023-10-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundParaquat, one of the most widely used herbicides, poses a significant risk of mortality through self-poisoning and subsequent multiple organ failure. The primary objective aimed to identify the factors associated with death in patients poisoned by paraquat.MethodsA cross-sectional retrospective review was conducted at a tertiary referral hospital over five years. Eligible patients presented with acute paraquat toxicity between 1 January 2016 and 31 December 2020. Medical records of 148 patients were reviewed.ResultsThe in-hospital fatality rate was found to be 21.8%. Multivariate analysis revealed that the amount of paraquat ingested and clinical presentations, particularly pulmonary and cardiovascular system disorders, were significantly associated with mortality.ConclusionOur study highlights that the amount of paraquat ingested, along with the presence of pulmonary and cardiovascular system disorders, can serve as prognostic indicators for mortality rates in cases of paraquat poisoning. These findings have important implications for physicians in predicting the prognosis and mortality of paraquat poisoning patients.Graphical Abstract

【 授权许可】

CC BY   
© Dr. Zaheer-Ud-Din Babar and Auckland UniServices Ltd. 2023

【 图 表 】

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