Menstrual cycle length: a surrogate measure of reproductive health capable of improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART

Reproductive Biology and Endocrinology

Research

Decio Armanini¹  Michela Quaranta²  Alessandra Andrisani³  Pietro Litta³  Salvatore Gizzo³  Marco Noventa³  Federica Esposito³  Michele Gangemi³  Guido Ambrosini³  Giovanni B Nardelli³  Donato D’Antona³ 

[1] Department of Medicine-Endocrinology, University of Padua, Giustiniani 2 street, 35128, Padua, Italy;Department of Obstetrics and Gynaecology, University of Verona, Piazzale Ludovico Scuro 10 street, 37134, Verona, Italy;Department of Woman and Child Health, University of Padua, Gynecologic and Obstetric Clinic, Giustiniani 3 street, 35128, Padua, Italy;

关键词: Menstrual cycle length;    Estimation of reproductive chances;    Ovarian sensitivity index;    Ovarian reserve;    Ovarian response;    Fertilization rate;    Pregnancy rate;    Infertility;   

DOI  :  10.1186/s12958-015-0024-1

 received in 2015-01-21, accepted in 2015-03-31,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAim of the study was to investigate whether menstrual cycle length may be considered as a surrogate measure of reproductive health, improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART.MethodsA retrospective-observational-study in Padua’ public tertiary level Centre was conducted. A total of 455 normo-ovulatory infertile women scheduled for their first fresh non-donor IVF/ICSI treatment. The mean menstrual cycle length (MCL) during the preceding 6 months was calculated by physicians on the basis of information contained in our electronic database (first day of menstrual cycle collected every month by telephonic communication by single patients). We evaluated the relations between MCL, ovarian response to stimulation protocol, oocytes fertilization ratio, ovarian sensitivity index (OSI) and pregnancy rate in different cohorts of patients according to the class of age and the estimated ovarian reserve.ResultsIn women younger than 35 years, MCL over 31 days may be associated with an increased risk of OHSS and with a good OSI. In women older than 35 years, and particularly than 40 years, MCL shortening may be considered as a marker of ovarian aging and may be associated with poor ovarian response, low OSI and reduced fertilization rate. When AMH serum value is lower than 1.1 ng/ml in patients older than 40 years, MCL may help Clinicians discriminate real from expected poor responders. Considering the pool of normoresponders, MCL was not correlated with pregnancy rate while a positive association was found with patients’ age.ConclusionsMCL diary is more predictive than chronological age in estimating ovarian biological age and response to COH and it is more predictive than AMH in discriminating expected from real poor responders. In women older than 35 years MCL shortening may be considered as a marker of ovarian aging while chronological age remains most accurate parameter in predicting pregnancy.

【 授权许可】

CC BY   
© Gizzo et al.; licensee BioMed Central. 2015