Respiratory Research | |
Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF | |
Letter to the Editor | |
Michiko Mori1  Jonas S. Erjefält1  Abraham B. Roos2  Axel Lorentz3  Martin R. Stampfli4  Harpreet K. Gura5  Hans Jürgen Hoffmann5  Leif Bjermer6  | |
[1] Department of Experimental Medical Science, Lund University, Lund, Sweden;Department of Experimental Medical Science, Lund University, Lund, Sweden;Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada;AstraZeneca R&D Gothenburg, Respiratory, Inflammation and Autoimmunity, Innovative Medicines, Pepparedsleden 1, 431 83, Mölndal, Sweden;Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany;Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada;Department of Medicine, Firestone Institute of Respiratory Health at St. Joseph’s Health Care, Hamilton, ON, Canada;Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark;Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden; | |
关键词: Vascular Endothelial Growth Factor; Chronic Obstructive Pulmonary Disease; Mast Cell; Chronic Obstructive Pulmonary Disease Patient; Vascular Remodel; | |
DOI : 10.1186/s12931-017-0534-9 | |
received in 2017-02-10, accepted in 2017-03-02, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
Files | Size | Format | View |
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RO202311105804139ZK.pdf | 721KB | download |
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