Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Respiratory Research

Letter to the Editor

Michiko Mori¹  Jonas S. Erjefält¹  Abraham B. Roos²  Axel Lorentz³  Martin R. Stampfli⁴  Harpreet K. Gura⁵  Hans Jürgen Hoffmann⁵  Leif Bjermer⁶ 

[1] Department of Experimental Medical Science, Lund University, Lund, Sweden;Department of Experimental Medical Science, Lund University, Lund, Sweden;Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada;AstraZeneca R&D Gothenburg, Respiratory, Inflammation and Autoimmunity, Innovative Medicines, Pepparedsleden 1, 431 83, Mölndal, Sweden;Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany;Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada;Department of Medicine, Firestone Institute of Respiratory Health at St. Joseph’s Health Care, Hamilton, ON, Canada;Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark;Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden;

关键词: Vascular Endothelial Growth Factor;    Chronic Obstructive Pulmonary Disease;    Mast Cell;    Chronic Obstructive Pulmonary Disease Patient;    Vascular Remodel;   

DOI  :  10.1186/s12931-017-0534-9

 received in 2017-02-10, accepted in 2017-03-02,  发布年份 2017

来源: Springer

【 摘 要 】

Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.

【 授权许可】

CC BY   
© The Author(s). 2017