Lasers, stem cells, and COPD

Journal of Translational Medicine

Review

Vincent Gammill¹  Vladimir Bogin²  Amit N Patel³  Constantin A Dasanu⁴  Famela Ramos⁵  Steven F Josephs⁵  David R Koos⁵  Feng Lin⁵  Doru T Alexandrescu⁶  Ewa Carrier⁷  Rosalia De Necochea-Campion⁷ 

[1] Center for the Study of Natural Oncology, Del Mar, CA, USA;Cromos Pharma Services, Longview, WA, USA;Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT, USA;Department of Hematology and Medical Oncology, St Francis Hospital and Medical Center, Hartford, CT, USA;Entest BioMedical, San Diego, CA, USA;Georgetown Dermatology, Washington, DC, USA;Moores Cancer Center, University of California San Diego, CA, USA;

关键词: Chronic Obstructive Pulmonary Disease;    Mesenchymal Stem Cell;    Stem Cell Therapy;    Nitrofurazone;    Peripheral Blood Mononuclear Cell Proliferation;   

DOI  :  10.1186/1479-5876-8-16

 received in 2010-01-07, accepted in 2010-02-16,  发布年份 2010

来源: Springer

【 摘 要 】

The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a non-invasive, non-thermal intervention that has the potential to modulate regenerative processes is worthy of attention when searching for novel methods of augmenting stem cell-based therapies. Here we discuss the use of LLL irradiation as a "photoceutical" for enhancing production of stem cell growth/chemoattractant factors, stimulation of angiogenesis, and directly augmenting proliferation of stem cells. The combination of LLL together with allogeneic and autologous stem cells, as well as post-mobilization directing of stem cells will be discussed.

【 授权许可】

Unknown   
© Lin et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.