Supraclavicular lymph node incisional biopsies have no influence on the prognosis of advanced non-small cell lung cancer patients: a retrospective study

World Journal of Surgical Oncology

Research

Wen-zhao Zhong¹  Xue-ning Yang¹  Song Dong¹  Jin-ji Yang¹  Qiang Nie¹  Yi-long Wu¹  Hong-hong Yan¹  Chong-rui Xu¹  Ri-qiang Liao¹  Ning Zhao²  Hui-wen Sun³  Fei-yu Niu³  Feng Li³  Qiu-yi Zhang³  Wei Deng³ 

[1] Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, 106 Zhongshan 2nd Road, 510080, Guangzhou, People’s Republic of China;Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, 106 Zhongshan 2nd Road, 510080, Guangzhou, People’s Republic of China;Department of Thoracic Surgery, The First People’s Hospital of Foshan, Foshan, People’s Republic of China;Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, 106 Zhongshan 2nd Road, 510080, Guangzhou, People’s Republic of China;Southern Medical University, Guangzhou, People’s Republic of China;

关键词: Non-small cell lung cancer;    Supraclavicular lymph node;    Incisional biopsy;   

DOI  :  10.1186/s12957-016-1064-5

 received in 2016-02-21, accepted in 2016-12-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSupraclavicular lymph node (SCLN) biopsies play an important role in diagnosing and staging lung cancer. However, not all patients with SCLN metastasis can have a complete resection. It is still unknown whether SCLN incisional biopsies affect the prognosis of non-small cell lung cancer (NSCLC) patients.MethodsPatients who were histologically confirmed to have NSCLC with SCLN metastasis were enrolled in the study from January 2007 to December 2012 at Guangdong Lung Cancer Institute. The primary endpoint was OS, and the secondary endpoints were complications and local recurrence/progression.ResultsTwo hundred two consecutive patients who had histologically confirmed NSCLC with SCLN metastasis were identified, 163 with excisional and 39 with incisional biopsies. The median OS was not significantly different between the excisional (10.9 months, 95% CI 8.7–13.2) and incisional biopsy groups (10.1 months, 95% CI 6.3–13.9), P = 0.569. Multivariable analysis showed that an Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥2 (HR = 2.75, 95% CI 1.71–4.38, P < 0.001) indicated a worse prognosis. Having an epidermal growth factor receptor (EGFR) mutation (HR = 0.58, 95% CI 0.40–0.84, P = 0.004) and receiving systemic treatment (HR = 0.36, 95% CI 0.25–0.53, P < 0.001) were associated with a favorable OS. Neither the number (multiple vs. single) nor site (bilateral vs. unilateral) of SCLNs was associated with an unfavorable OS, and SCLN size or fixed SCLNs did not affect OS.ConclusionsSCLN incisional biopsies did not negatively influence the prognosis of NSCLC patients. It was safe and feasible to partly remove a metastatic SCLN as a last resort in advanced NSCLC.

【 授权许可】

CC BY   
© The Author(s). 2017