BMC Medical Imaging | |
Use of fuzzy edge single-photon emission computed tomography analysis in definite Alzheimer's disease - a retrospective study | |
Research Article | |
Robert Rusina1  Marie Buncová2  Radoslav Matěj3  Tomáš Bělíček4  Jaromír Kukal4  | |
[1] Department of Neurology, Thomayer Teaching Hospital and Institute for Postgraduate Education in Medicine, Prague, Czech Republic;Department of Nuclear Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;Department of Pathology and Molecular Medicine, Thomayer Teaching Hospital, Prague, Czech Republic;Department of Software Engineering in Economy, Faculty of Nuclear Science and Physical Engineering, Czech Technical University, Prague, Czech Republic; | |
关键词: Single Photon Emission Computerize Tomography; Single Photon Emission Computerize Tomography Image; Single Photon Emission Computerize Tomography Study; Single Photon Emission Computerize Tomography Data; Posterior Cingulate Gyrus; | |
DOI : 10.1186/1471-2342-10-20 | |
received in 2010-01-26, accepted in 2010-09-01, 发布年份 2010 | |
来源: Springer | |
【 摘 要 】
BackgroundDefinite Alzheimer's disease (AD) requires neuropathological confirmation. Single-photon emission computed tomography (SPECT) may enhance diagnostic accuracy, but due to restricted sensitivity and specificity, the role of SPECT is largely limited with regard to this purpose.MethodsWe propose a new method of SPECT data analysis. The method is based on a combination of parietal lobe selection (as regions-of-interest (ROI)), 3D fuzzy edge detection, and 3D watershed transformation. We applied the algorithm to three-dimensional SPECT images of human brains and compared the number of watershed regions inside the ROI between AD patients and controls. The Student's two-sample t-test was used for testing domain number equity in both groups.ResultsAD patients had a significantly reduced number of watershed regions compared to controls (p < 0.01). A sensitivity of 94.1% and specificity of 80% was obtained with a threshold value of 57.11 for the watershed domain number. The narrowing of the SPECT analysis to parietal regions leads to a substantial increase in both sensitivity and specificity.ConclusionsOur non-invasive, relatively low-cost, and easy method can contribute to a more precise diagnosis of AD.
【 授权许可】
CC BY
© Rusina et al; licensee BioMed Central Ltd. 2010
【 预 览 】
Files | Size | Format | View |
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RO202311105736968ZK.pdf | 1282KB | download |
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