The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism

Lipids in Health and Disease

Review

Mengdie Luo¹  Daoquan Peng¹ 

[1] Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;

关键词: Apolipoproteins;    Atherosclerosis;    Gene therapy;   

DOI  :  10.1186/s12944-016-0352-y

 received in 2016-07-13, accepted in 2016-10-14,  发布年份 2016

来源: Springer

【 摘 要 】

Apolipoprotein C-III has been referred to as an important participant in the metabolism of triglyceride-rich lipoproteins, leading to hypertriglyceridemia and thereafter cardiovascular disease. Accumulating evidence indicates that apolipoprotein C-III is a multifaceted protein which not only regulates triglyceride metabolism, but also participates in the atherosclerotic lesion formation and several other pathological processes involved in atherosclerosis. Based on data from experiments and clinical trials, some novel therapies such as antisense technology emerge.

【 授权许可】

CC BY   
© The Author(s). 2016