Papillary thyroid microcarcinoma: the significance of high risk features

BMC Cancer

Research Article

Nori L. Bradley¹  Sam M. Wiseman¹ 

[1] Department of Surgery, St. Paul’s Hospital & University of British Columbia, St. Paul’s Hospital Department of Surgery, Room C303, Burrard Building, 1081 Burrard Street, V6Z 1Y6, Vancouver, BC, Canada;

关键词: Thyroid Cancer;    Thyroid Carcinoma;    Papillary Carcinoma;    Microcarcinoma;    Prognosis;   

DOI  :  10.1186/s12885-017-3120-0

 received in 2016-01-23, accepted in 2017-02-07,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPapillary carcinomas that measure 1.0cm or less are diagnosed as papillary thyroid microcarcinomas (PTMs). The clinical significance and recommendations for management of these PTMs is still evolving. The objective of the study was to compare the characteristics of small (<5mm) to large (≥ 5mm) papillary thyroid microcarcinomas.MethodsAmongst 1459 sequential patients undergoing thyroid surgery at a single center, 132 (9%) cases were diagnosed with PTM. We performed a retrospective analysis of these cases using Fisher’s Exact Test. The statistical significance was set at p < 0.05 a priori.ResultsA relationship between large PTM and high risk features was observed only for extra-thyroidal cancer extension (ETE). Six of 57 large PTM (11%) but none of the 75 small PTM had ETE (p < 0.01). Lymph node metastases were associated with both small PTM (5/9 cases) and large PTM (4/9 cases). A distant metastases was diagnosed in association with a small PTM.ConclusionsFor PTM, neither small cancer size, nor the absence of high-risk features, excluded the possibility of synchronous lymph node metastases.

【 授权许可】

CC BY   
© The Author(s). 2017