5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

BMC Cancer

Research Article

Zhiyong Qian¹  Yongsheng Wang¹  Yuquan Wei¹  Shuai Shi¹  Li Yang¹  Changyang Gong¹  Qinjie Wu¹  Huashan Shi¹ 

[1] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, China;

关键词: Methylene Blue;    Pluronic;    Peritoneal Carcinomatosis;    Triblock Copolymer;    Intraperitoneal Chemotherapy;   

DOI  :  10.1186/1471-2407-10-402

 received in 2009-10-30, accepted in 2010-08-02,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundColorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy.MethodsA biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model.ResultsThe hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity.ConclusionsOur data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers.

【 授权许可】

CC BY   
© Wang et al; licensee BioMed Central Ltd. 2010