Malignant acrospiroma: a case report in the era of next generation sequencing

BMC Cancer

Case Report

Muaiad Kittaneh¹  Maria Diab²  Ali Gabali³ 

[1] Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA;Department of Internal Medicine, Wayne State University, School of Medicine, Detroit, MI, USA;Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, USA;

关键词: Acrospiroma;    Malignant;    Acral;    Next generation;    Case report;   

DOI  :  10.1186/s12885-017-3217-5

 received in 2016-02-21, accepted in 2017-03-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMalignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.Case presentationWe herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.ConclusionTo the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.

【 授权许可】

CC BY   
© The Author(s). 2017