Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

Lipids in Health and Disease

Review

Muhammad Imran¹  Muhammad Tauseef Sultan²  Muhammad Umair Arshad³  Muhammad Sajid Arshad⁴  Masood Sadiq Butt⁵  Joong-Ho Kwon⁶ 

[1] Department of Diet and Nutritional Sciences, Imperial College of Business Studies, Lahore, Pakistan;National institute of Food Science and Technology, University of Agriculture Faisalabad, Faisalabad, Pakistan;Department of Food Science and Technology, Bahauddin Zakariya University, Multan, Pakistan;Institute of Home and Food Sciences, Government College University, 36000, Faisalabad, Pakistan;Institute of Home and Food Sciences, Government College University, 36000, Faisalabad, Pakistan;School of Food Science and Biotechnology, Kyungpook National University, 41566, Daegu, Republic of South Korea;National institute of Food Science and Technology, University of Agriculture Faisalabad, Faisalabad, Pakistan;School of Food Science and Biotechnology, Kyungpook National University, 41566, Daegu, Republic of South Korea;

关键词: Bioactive molecules;    Human cancers;    Mangiferin;    Nutrition;    Health claims;    Toxicity;   

DOI  :  10.1186/s12944-017-0449-y

 received in 2016-12-19, accepted in 2017-03-09,  发布年份 2017

来源: Springer

【 摘 要 】

The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

【 授权许可】

CC BY   
© The Author(s). 2017