Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations

Lipids in Health and Disease

Research

Hui Li¹  Yi-Ming Wang²  Dong-Feng Wu³  Qing Li³  Rui-Xing Yin³  Lynn Htet Htet Aung³  Ting-Ting Yan³  De-Zhai Yang⁴  Yuan-Lu Shi⁵  Dai-Xun Wei⁵ 

[1] Clinical Laboratory of the Affiliated Cancer Hospital, Guangxi Medical University, 71 Hedi Road, 530021, Nanning, People's Republic of China;College of Stomatology, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi, People's Republic of China;Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, 530021, Nanning, Guangxi, People's Republic of China;Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, 22 Shuangyong Road, 530021, Nanning, Guangxi, People's Republic of China;The Center for Disease Control and Prevention of Luocheng Mulao Autonomous County, Luocheng, 546400, Hechi, Guangxi, People's Republic of China;

关键词: Serum Lipid Level;    Rs17321515 Single Nucleotide Polymorphism;    ApoA1 Level;    ApoB Level;    Guangxi Zhuang Autonomous Region;   

DOI  :  10.1186/1476-511X-10-230

 received in 2011-10-30, accepted in 2011-12-06,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe association of rs17321515 single nucleotide polymorphism (SNP) near TRIB1 gene and serum lipid profiles has never been studied in the Chinese population. Therefore, the present study was undertaken to detect the association of rs17321515 SNP and several environmental factors on serum lipid levels in the Mulao and Han populations.MethodsA total of 639 unrelated subjects of Mulao nationality and 644 participants of Han nationality were randomly selected from our previous stratified randomized cluster samples. Genotypes of the TRIB1 rs17321515 A>G SNP were determined via polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing.ResultsSerum apolipoprotein (Apo) B levels were higher in Mulao than in Han (P < 0.05). There were no differences in the genotypic and allelic frequencies between the two ethnic groups (P > 0.05). High- and low-density lipoprotein cholesterol (HDL-C and LDL-C) levels in Han were different among the genotypes (P < 0.05 for each), the subjects with AG/GG genotypes had higher HDL-C and LDL-C levels than the subjects with AA genotype. Total cholesterol (TC), HDL-C, LDL-C, ApoA1 and ApoB levels in Han males were different among the genotypes (P < 0.05-0.001), the G carriers had higher TC, HDL-C, LDL-C, ApoA1 and ApoB levels than the G noncarriers. HDL-C levels in Mulao males were different among the genotypes (P < 0.05), the G carriers had lower HDL-C levels than the G noncarriers. Serum HDL-C and LDL-C levels in both ethnic groups and TG levels in Han were correlated with the genotypes or alleles (P < 0.05-0.01). TG and HDL-C levels in Mulao males and TG, HDL-C, LDL-C and ApoA1 levels in Han males were correlated with genotypes or alleles (P < 0.05-0.001). TG and ApoA1 levels in Han females were associated with genotypes (P < 0.05 for each). Serum lipid parameters were also associated with several environmental factors in both ethnic groups.ConclusionsThe associations of TRIB1 rs17321515 SNP and serum lipid levels are different between the Mulao and Han populations. These discrepancies might partly result from different TRIB1 gene-environmental interactions in both ethnic groups.

【 授权许可】

Unknown   
© Aung et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.